Article ID: JJID.2017.090
OP-145 is a synthetic antimicrobial peptide developed from the human cathelicidin LL-37. The purpose of this investigation was to evaluate the effect of the antimicrobial peptide OP-145 against clinically isolated drug resistant strains. Ten Methicillin-resistant Staphylococcus aureus (MRSA) strains were obtained from our hospital's clinical inspection center and the activity of OP-145 on growth and biofilm formation on these strains was evaluated by colony counts and scanning electron microscopy. The antimicrobial peptide OP-145 showed significant antibacterial activity against 9 MRSA strains. For the biofilm experiments, MRSA counts in the biofilms decreased significantly after 24h (P ＜ 0.05). OP-145 strongly reduced growth and biofilm formation of clinically isolated drug resistant strains in vitro, and the use of this class of antimicrobial agents may be an important new approach in controlling bacterial infections.
