Predominant detection of the subgroup A2b human metapneumovirus strain with 111-nucleotide duplication in Yokohama City, Japan in 2018

Miwako Saikusa; Naganori Nao; Chiharu Kawakami; Shuzo Usuku; Nobuko Tanaka; Maino Tahara; Makoto Takeda; Ichiro Okubo

doi:10.7883/yoken.JJID.2019.124

This article has now been updated. Please use the final version.

Predominant detection of the subgroup A2b human metapneumovirus strain with 111-nucleotide duplication in Yokohama City, Japan in 2018

Miwako Saikusa, Naganori Nao, Chiharu Kawakami, Shuzo Usuku, Nobuko Tanaka, Maino Tahara, Makoto Takeda, Ichiro Okubo

Author information

Keywords: Human metapneumovirus, G gene, Nucleotide duplication, surveillance

JOURNAL FREE ACCESS Advance online publication

Article ID: JJID.2019.124

DOI https://doi.org/10.7883/yoken.JJID.2019.124

The final version of this article is now available: Vol. 72 (2019), No. 5 pp. 350-352

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Abstract

Human metapneumovirus (HMPV) has been a major causative agent of acute respiratory infections in humans. Recently two types of variant A2b subtype HMPV strains possessing 111- or 180-nucleotide duplication (nt-dup) in the G gene (HMPV A2b_180nt-dup and HMPVA2b_111nt-dup, respectively) were detected in Japan, Spain, Vietnam, and China. Surveillance for infectious agents in Yokohama City, Japan revealed that the HMPV_111nt-dup strain became predominant in Yokohama City in 2018. In contrast, no classical HMPV A2b strain was detected after 2017. These data suggest a beneficial role of the 111nt-dup in the G gene for the transmission of HMPV.

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