ON THE HEMOLYTIC ACTION OF ο-AMINOPHENOL AZO-PROTEIN DERIVATIVES
1949 Volume 2 Issue 3 Pages 130-136
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1949 Volume 2 Issue 3 Pages 130-136
Our preliminary paper appeared in October, 1945 (1) reported, in so far as we knew, the first experimental evidence that O.A.-azo-tuberculin gives powerful tuberculin skin reaction in tuberculous guinea-pigs, and has very low toxicity for guineapigs infected with a human strain of tubercle bacilli.
While engaged in the study of the pharmacological action of O.A.azo-tuberculin.n derivatives, we have recently noticed a curious phenomenon indicating that O. A.-azo-tuberculin dissolves the red blood cells.
In view of this finding, it was also of interest to study the effect of various aminophenol azo-protein derivatives upon red blood cells. For this purpose, a number of azo-protein derivatives were prepared and tested for their hemolytic activity, and the results are reported in the present communication.
