Japanese Journal of Medical Science and Biology
Online ISSN : 1884-2828
Print ISSN : 0021-5112
ISSN-L : 0021-5112
GROWTH RESPONSE TO 60Co γ-IRRADIATION OF HUMAN CELL LINES CULTIVATED IN VITRO II. STABLE CHANGE IN RADIORESISTANCE OF HeLa STRAIN CELLS MANIFESTED THROUGH REPEATED IRRADIATION
高野 宏一広川 康子浅野 正英雨森 良彦道 健一
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1962 年 15 巻 1 号 p. 19-27

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In the previous paper (Takano et al., 1961), the fundamental behavior of several human cell lines to 60Co γ-irradiation was described on the basis of dose-response curve estimated by the cell population 7 days after irradiation. The human uterus cancer HeLa strain was subjected to irradiation with a dose of 2000r, and surviving cells were grown to form colonies. As the result, a cell group developed with a little increased tendency in radioresistance.
In the present study, the irradiation and cultivation were repeated up to 5 times or 10, 000r in the accumulated dose, and some stable changes in radioresistance and other biological characters of the HeLa cells were revealed to have occurred.
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