Japanese Journal of Medical Science and Biology
Online ISSN : 1884-2828
Print ISSN : 0021-5112
ISSN-L : 0021-5112
ON THE BIOLOGICAL ASSAY OF TOXICITY OF PERTUSSIS VACCINE USING MICE* II. SOME CONSIDERATIONS ON THE LEVEL OF TOXICITY PASSING THE CURRENT REGULATION
黒川 正身石田 説而倉塚 和夫堀江 喜一藤崎 優次郎入沢 純開島崎 義男大杉 チエ子船坂 勇
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1962 年 15 巻 2-3 号 p. 85-96

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A biological assay method for toxicity of pertussis vaccine was proposed in the previous paper (Kurokawa et al., 1962) . By the method it was expected to enable a quantitative determination of toxicity and to give more reproducible estimates than the current method because it was designed to control the variation in the mean response of animals at different times or in different laboratories.
The present paper is chiefly concerned with expressing the level of toxicity passing the current regulation in terms of the relative toxicity. The considerations were made chiefly being based on the results from the experiments using mice, which have been carried out relatively in detail and were presented in the previous paper. Experimental data obtained with guinea pigs also were referred to in the considerations.
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