Abstract
Attempts at determination of the organic sources of serum alkaline phosphatase (ALP) have been undertaken with Goettingen miniature pigs with ligature of common bile duct. This was a part of the whole study on the utility of the Goettingen miniature pigs for biomedical researches.
The activity of serum ALP rose up promptly after the ligature of common bile duct and reached a peak at day 3 from the ligature, with leveling thereafter.
There were no major changes thereafter.
In any of the organs examined, the ALP activity tended to rise and this tendency was especially notable in liver.
The enzimo-histochemistry of the ALP activity in the animals with ligature of common bile duct revealed that the ALP activity of capillary bile duct was higher in them than in the animals of the control group. In addition, it was revealed that the ALP activity on the sinusoidal side of the hepatocellular membrane was also high.
The above-mentioned findings suggested that the ALP activity in serum as seen following the ligature of common bile duct is originated from liver where synthesis of ALP is assumed to take place.
