Preparation of functionalized organometallic reagents is widely used in organic synthesis. Convenient, practical, and economical methods for preparation of functionalized organometallics were highly demanded. Recently, Knochel et al. reported direct metal insertion into carbon-halogen bond was dramatically promoted in the presence of lithium chloride. This method was applicable to prepare organozinc, -magnesium, and -indium reagents.
2009 社団法人 有機合成化学協会