Palladium-and nickel-catalyzed cross-coupling reactions are indispensable tool for organic synthesis. Despite the wide application profile of this methodology, the search for feasible alternatives of these catalysts is highly demanded from the practical viewpoints. Recently, iron catalysts, which are environmentally friendly and economical, are found to be applicable to various cross-coupling reactions, including both C-C and C-X (X = hetero atom) bond forming reactions. These reactions can be conducted with simple procedure under mild conditions and are compatible with a variety of functional groups in both reaction partners.
2010 社団法人 有機合成化学協会