Journal of Synthetic Organic Chemistry, Japan
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
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Pd0-Mediated Rapid C-[11C]Methylations and C-[18F]Fluoromethylations: Revolutionary New Methodologies for the Synthesis of Short-Lived PET Molecular Probes
Masaaki SuzukiHisashi Doi
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JOURNAL OPEN ACCESS

2010 Volume 68 Issue 11 Pages 1195-1206

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Abstract
A revolutionary new methodology for introducing a short-lived radionuclide 11C into carbon frameworks of biologically significant organic compounds has been established by developing rapid C-[11C]methylations and C-[18F]fluoromethylations using Pd0-mediated cross-coupling reactions between [11C]methyl iodide or [18F]fluoromethyl iodide (or bromide) and excess amounts of organostannane or organoboron compounds. These rapid reactions provide firm chemical bases for an efficient, general synthesis of short-lived 11C- and 18F-labeled PET molecular probes in order to strongly promote in vivo molecular science.
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© 2010 The Society of Synthetic Organic Chemistry, Japan
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