リン酸基転位反応に対する反応機構の解明と人工酵素の開発

抄録

Phosphoryl transfer reactions are one of the most important reactions in biological system and intense efforts have been devoted to understand the mechanism. Recently, some X-ray analyses of tri- and pentacoordinate phosphorus-enzyme complex as intermediates of phosphoryl transfer reactions were reported. In addition, highly reactive dinuclear Zn (II) complexes are recently reported to catalyze phosphoryl transfer reaction and used for the verification of the reaction mechanism.