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有機合成化学協会誌
Vol. 68 (2010) No. 9 P 962-963

記事言語:

http://doi.org/10.5059/yukigoseikyokaishi.68.962

Review de Debut

Fluorinated compounds have drawn the attention of medicinal chemists because of their potential metabolic tolerance and modulation of drug efficacy. Thus stereo- and enantioselective construction of fluorinated carbon center is an important issue. In spite of remarkable progress in the last decade, the first effective method of catalytic enantioselective fluorination by nucleophilic fluorine reagent has been reported in this year. In this article, construction of fluorinated chiral center is reviewed being categolized into three classes.

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