Recent progress in asymmetric synthesis based on the formation of chiral boron “ate” complex is overviewed. Hoppe and Aggarwal have reported stereo-controlled homologation of chiral boron “ate” complex via stereoselective 1,2-rearrangement. Aggarwal has also observed the inversion of stereochemistry during the formation of boron “ate” complex, in the reaction of sterically-hindered chiral carbanion with boronic acid ester. These results will provide a new direction to the field of asymmetric synthesis.
2012 社団法人 有機合成化学協会