Meta Selective C-H Bond Functionalization

Abstract

Substituted arenes are important building blocks for many natural products, medicines and materials. Functionalization of unactivated carbon-hydrogen (C-H) bonds is an efficient strategy for preparation of these compounds without substrate prefunctionalization. The traditional C-H activation methods utilized proximate heteroatom directing groups that direct selective cleavage of ortho C-H bonds and formconformationally rigid metallacycles. However, recent advances in the field have enabled meta-selective C-H functionalizations.