Abstract
DNA is an attractive chiral source because of its unique helical chirality. Recently, DNA-based hybrid catalysts, self-assembled from DNA and a metal complex with a specific ligand through supramolecular or covalent anchoring strategies, have been developed and applied successfully in a variety of carbon-carbon or carbon-heteroatom bond-forming reactions. Now these enticing biohybid catalysts are expanding their role in asymmetric synthesis. In this review, we summarize the advent and significant progress of DNA-based asymmetric catalysis and discuss remaining challenges for future applications of DNA-based hybrid catalysts.
