Development of Catalytic Asymmetric Reactions Based on Conformational Control

Abstract

In this review, our studies in relation to development of catalytic asymmetric reactions based on conformational control, are embodied, which are divided by content into four sections as follows: (1) asymmetric Grignard cross-coupling reaction with Pd and a N-Ar axially chiral mimetic-type ligand catalyst; (2) asymmetric intramolecular α-arylation of N-(2-bromophenyl)-2-arylpropanamides with Pd and a chiral mimetic-type N-heterocyclic carbene ligand catalyst; (3) asymmetric arylation of aromatic aldehydes using phenylboronic acid with Rh and a hemilabile phosphorus ligand based on conformational control; (4) asymmetric arylation of conformatinally fixed aromatic aldehydes bearing an ortho-Me₂PhSi group, using potassium 1-aryl-4-methyl-2,6,7-trioxa-1-boranuidabicylo[2.2.2]octanes as aryl sources with Ni and a (R,R)-Et-duphos ligand catalyst.