Palladium-Catalyzed Asymmetric C(sp³)-H Arylation

Abstract

Asymmetric C-H functionalization is an efficient synthetic method for highly enantioenriched molecules. Recently, highly enantioselective arylations of unactivated C(sp³)-H bonds have been established using chiral palladium catalyst systems. In these reactions, chiral monodentate ligand and carboxylic acid act as key elements to achieve high catalyst activity and enantioselectivity.