Application of Flow Micro Synthesis Technology for Medicinal Chemistry

Abstract

In recent years, the micro-flow synthesis technologies have been attracting attention as the new technologies alternative to a batch reaction. Mainly, these technologies are being utilized in the field of the CMC by taking advantage of easy scale-up reactions. On the other hand, each company is exploring how to use these technologies in the field of medicinal chemistry. Although I have experienced for 20 years as medicinal chemist, I felt it was difficult to apply these technologies in the work-flow of medicinal chemistry. But in these few years, many interesting articles by medicinal chemists have been reported for example, the application of library synthesis. In this review, I will present the recent information of using flow-micro synthesis technologies as the view point of Medicinal Chemist.