2016 年 74 巻 11 号 p. 1047-1057
This account describes our studies on the transition-metal mediated transformation of tetrafluoroethylene into a variety of polyfluorinated organic compounds. We have divided our account into three main parts. First, we describe a series of palladium-catalyzed cross-coupling reactions that involve a C-F bond cleavage of tetrafluoroethylene as a key elementary reaction step. Also described are reactions that enable the construction of tetrafluoroethylene-bridging structures, such as R-CF2CF2-R’ and R-CF2CF2-H, from tetrafluoroethylene using either copper(I) or nickel(0) species. This account emphasizes the merits of a derivatization of readily available perfluorinated compounds to valuable highly fluorinated organic compounds.