2016 Volume 74 Issue 9 Pages 885-902
Regio- and stereoselective allylic substitution is an important tool for the synthesis of complex organic molecules. Due to the high branched-product selectivity, iridium gives a new opportunity in enantioselective synthesis. Iridium-catalyzed enantioselective allylic substitution is one of the most reliable methods for the synthesis of chiral building blocks. This review gives a comprehensive survey of iridium-catalyzed enantioselective allylic substitution. Iridium catalysts are divided into two types; iridacycle and bidentate (P, alkene) iridium complex. Iridacycle catalyst is suitable for the reaction of primary allylic electrophiles. On the other hand, bidentate (P, alkene) iridium catalyst is suitable for the reaction of racemic secondary allylic electrophiles.
