Construction of Quaternary Stereocenter based on Organocatalytic Dearomatization Reaction

Abstract

The asymmetric dearomatization reaction of phenols and their derivatives has emerged as a powerful method for the construction of enantioenriched cyclic enones, which are frequently found in bioactive natural products and pharmaceuticals. This review focuses on recent progress for construction of quaternary stereocenter based on organocatalytic dearomatization reaction.