Carbohydrate Synthesis Using Fluorous Chemistry

Abstract

Fluorous solvents are generally immiscible with common organic solvents. Using to this unique property, “fluorous technique” has spread across various fields, including those of synthetic, catalytic, and analytical chemistry. In synthetic chemistry, a fluorous chemistry is suitable as a strategic alternative to solid-phase synthesis, because it does not inevitably resort to chromatography. In this paper, the efficient synthesis of monosaccharide units and oligosaccharide by the use of fluorous methods is reported. Further, the synthesis of a monosaccharide unit using the combination of fluorous chemistry and a microreactor as a single system is described. Additionally, oligosaccharide library synthesis by fluorous mixture method is reported.