2018 年 76 巻 3 号 p. 257-258
Pleuromutilin is an antibiotic having protein synthesis inhibitory activity isolated from Pleurotus mutilus by Kavanagh and co-workers in 1951. Due to its unique pharmacological action mechanism, it is expected to be used as a medicine. Indeed, some of the semi-synthesized derivatives have already been approved as medicines and widely used. Two examples of asymmetric total synthesis reported in recent years are described focusing on the construction method of its framework.