Cu-catalyzed Transformations of Allenes: Use of in-situ Generated Allyl Copper Intermediates in Organic Synthesis

Abstract

Herein, Cu-catalyzed transformations using allenes as substrates are described. First, the borylative transformations of allenes are summarized including hydroboration, boraallylation, and boraformylation. We next deal with the silylative transformations of allenes such as silacarboxylation and silylative allylation of carbonyl compounds. The transformation involving the hydrocupration to allenes are also described. Hydrohydroxymethylation, hydrocarboxylation and hydroallylation were achieved. In each section, the synthesis and characterization of borylcopper, silylcopper and hydridocopper complexes which are important intermediates are briefly introduced.