究極の環境調和型有機合成を目指して—触媒的脱水型辻-Trost反応の最近の進展—

抄録

C-C coupling reaction is a fundamental process for construction of organic molecules. From the view point of environmentally benign organic synthesis, one of the most ideal process is catalytic dehydrative coupling reactions in which only water is produced as a waste. In this mini-review, Tsuji-Trost reaction of allyl alcohol with carbonyl compounds are described briefly as a representative process. Especially, Ni-catalyzed process employing aldehyde as a carbon pronucleophile recently developed by Sauthier et al. is introduced in detail. Their reaction do not require activator such as acid or base. The reaction condition they developed is also applicable for construction of a quaternary stereocenter with α, β-unsaturated aldehydes.