2018 年 76 巻 5 号 p. 410-413
Teleocidin B is a terpene indole isolated from bacteria. A methyltransfer enzyme in teleocidin B biosynthesis, TleD not only installs a methyl group on the geranyl moiety of the precursor, but also facilitates the nucleophilic attack from the electron-rich indole to the resultant cation, to form indole-fused cyclohexene ring. This study reports novel biosynthetic reaction in the field of terpene cyclization.