Review de Debut
有機溶媒に難溶なCsFを用いる触媒的不斉フッ素化反応の新展開
2020 年 78 巻 2 号 p. 158-159
詳細
2020 年 78 巻 2 号 p. 158-159
Metal fluorides such as KF and CsF are inexpensive and easy-to-handle nucleophilic fluorinating reagents while their insolubility in most organic solvents often causes a problem in their synthetic use. In this review, examples of nucleophilic fluorination promoted by a hydrogen-bonding donor are described. Moreover, a recent research on asymmetric nucleophilic fluorination using a chiral hydrogen-bond donor catalyst is introduced.
