Journal of Synthetic Organic Chemistry, Japan
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
Review de Debut
Organic Synthesis for Diversity Expansion of DNA Encoded Libraries
Shohei Hamada
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JOURNALS OPEN ACCESS

2020 Volume 78 Issue 8 Pages 813-815

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Abstract

DNA encoded library (DEL) has emerged as a widely utilized chemical library, possessing DNA-tag on each compound, for discovering hit compounds in drug discovery. However, synthetic methods for DEL are not fully exploited due to the difficulty in chemical transformation of DNA encoded compounds. This mini-review focuses on the recent development on organic synthesis for diversity expansion of DEL.

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© 2020 The Society of Synthetic Organic Chemistry, Japan
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