水素結合ドナーとしてのジフルオロメチル基

抄録

The difluoromethyl group attracts growing attention as a chemically stable lipophilic hydrogen bond donor. However, there have been limited experimental attempts to explore the hydrogen bonding nature of the group until recently. In this review, the fundamental properties of the difluoromethyl group elucidated by the recent studies are introduced, as well as applications for functional molecules.