2024 Volume 82 Issue 1 Pages 37-49
During the last 30 years, the field of “fluorous chemistry” has witnessed intriguing advancements in organic synthesis. Fluorous molecules possess an alluring characteristic of displaying remarkably high affinity towards similar molecules, despite not mixing well with organic solvents or water. This phenomenon is commonly referred to as the “fluorophilic effect.” As we stand on the brink of the 30th anniversary of the inception of fluorous chemistry, this paper introduces our recent research accomplishments concerning the utilization of intermolecular or intramolecular fluorophilic effects in synthetic reactions.
