Development of Continuous Flow Technology Handling Various Reaction Systems toward Manufacturing Drug Substances

Abstract

Toward manufacturing drug substances under continuous flow conditions, homogeneous reaction systems are generally preferred to enable the process control. However, this approach toward the homogeneous reaction systems limits the implementation scope of continuous flow technology and may deviate from the ideal process because various reaction systems including heterogeneous reaction systems have to be handled in the recent pharmaceutical development. The author tried to establish the technological platform to enable the control of the various reaction systems under continuous flow conditions, which will truly contribute to the dissemination of continuous flow technology in the pharmaceutical development.

Graphical Abstract