Photochemical Macrolactonization by Controlling Radical Reactivity

Abstract

Macrolactones are structurally important motifs found in a variety of natural products and bioactive compounds. Conventional approaches to their synthesis include the use of seco acids via activation of acid. This short review focuses on the recent progress in photochemical macrolactonization by controlling radical reactivity. The macrolactonization via radical processes introduces a new methodology for total synthesis of natural products.