Studies on the Condensation Reactions of Carboxylic Hydrazides and the Reactions between Carboxylic Hydrazides and Carboxylic Amides. I

Analytical Methods of the Reactants and the Products of the Condensation Reactions

Abstract

In order to confirm the condensation reaction of acetohydrazide and acetamide, separatory determinations of unreacted components as well as the supposed products, 3, 4-dimethyl-4-amino-1, 2, 4-triazole and 3, 4-dimethyl-4-aminotriazole, have been investigated. Acetohydrazide and 3, 4-dimethyl-4-amino-1, 2, 4-triazole were determined by iodometric method with accuracy of 99.0 % against the using of 0.1 mM sample. Acetohydrazide was analyzed from a mixture of 3, 5-dimethyl-4-amino-1, 2, 4-triazole with 99.0 % detection efficiency from using of 0.1 mM of the mixture by use of either K₂HgI₄, K₃Fe (CN) ₆ or KI0₃. Also, 0.1 mM of 3, 5-dimethy1-1, 2, 4-triazole was determined with 99.8 % accuracy by use of AgNO₃ method or 99.7 0% accuracy in the presence of a large excess of acetohydrazide by use of an improved method. Reproducible analytical data were obtained by using either single or mixed sample.