Abstract
Reaction of maleic anhydride with monoethanolamine, monopropanolamine, or monoisopropanolamine yielded N-β-oxyethylmaleamic acid, N-γ-oxypropylmaleamic acid, or N-β-oxyisopropylmaleamic acid, respectively. Dehydration of these maleamic acids with acetic anhydride and sodium acetate, followed by esterification gave N-acetoxyethylmaleimide, N-acetoxypropylmaleimide, or Nacetoxyisopropylisomaleimide, respectively. Dehydration and cyclization of N-β-oxyethylmaleamic acid with a small amount of sulfuric acid gave N-β-oxyethylmaleimide. Similar dehydration and esterification of N, O-dimaleoylaminoethanol gave N-(methylmaleoyl)ethylmaleimide. All of the above products are new compounds. Maleimide derivative was synthesized as a monomer in order to obtain its polymer.
