Journal of Synthetic Organic Chemistry, Japan
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
Reactions of α, α-dialkylsubstituted α-N-acylaminonitriles
Studies on Amino Acids. VI
Tadashi SHIRAIShuji KURASHIGE
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1973 Volume 31 Issue 1 Pages 88-93

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Abstract
In the previous paper, hydrolysis of α-alkyl and α, α-dialkyl N-acetylsarcosinonitriles and N-acetylglycinonitriles with alkali or acid was reported.
In both series it was found that under alkaline conditions α, α-dialkyl compounds mainly changed to intramolecular cyclization compounds (imidazalones) and in the case of glycino series there was an equilibrium between amide and imidazolone.
The imidazolones were also obtained under acidic conditions in both series, and in sarcosino series, the corresponding imidazoline-4-imide was formed in addition to the imidazolone.
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© The Society of Syhthetic Organic Chemistry, Japan
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