1982 Volume 40 Issue 11 Pages 968-973
Advances in structural organic chemistry in the past have been reviewed. In the past, intramolecular interaction was the main topic in structural organic chemistry as well as the synthesis of strained molecules and unusual compounds which have contributed to the advance in understanding of chemical bonding. In recent years, the interest of structural organic chemists seems to be changing from intramolecular to intermolecular interactions : reactions are now the target of study in this field. Incipient transition state which can be modeled by certain congested molecules and conformational effects on reactivity are cited. Quantitative understanding of the steric effect and the solvent effects on the molecular levels are the remaining problems in this field. Methodology, both theoretical and experimental, which potentially contributes in studying these problems is discussed.