Synthesis, Stereochemistry, and Biological Transformation of “Triblattanes” : A Series of Cage-shaped Compounds Possessing D₃ -Twisted Bicyclo [2.2.2] octane Core as a Common Structural Feature

Abstract

We have been interested in the chemistry of the gyrochiral cage-shaped molecules possessing D₃- twisted bicyclo [2.2.2] octane molecular framework as a common structural unit, and this article summarizes our recent studies on the synthesis, stereochemistry, and biological transformation of this unique group of cage-shaped molecules on which a generic name “triblattane”, has been coined to characterize their common structural feature.