Abstract
Iodotrimethylsilane which has a hard acid (Me3Si) -soft base (I) bond displays a strong oxygenophilicity towards ethers, esters, lactones, acetals, and other molecules involving oxygen atom as a functional group. Recent progress of the chemistry of iodotrimethylsilane is reviewed especially from a view point of organic synthesis. The application of bromotrimethylsilane to organic synthesis is also discussed briefly.
