Abstract
This review deals with the coimmobilization methods of coenzyme and enzymes and their application to continuous production of various materials in enzyme reactors. The methods are divided into four major groups according to the used form of coenzyme : water-soluble polymer-bound form, water-insoluble polymer-bound form, covalently enzyme-bound form, and native form. Each case is further divided into groups based on the practical use, system, or apparatus in view of how to use the coenzyme together with the enzymes. Typical examples are cited in some detail and their merits and demerits are discussed. Synthetic methods of polymer-bound coenzyme and regeneration system of coenzymes are also summarized.
