Abstract
The reaction of γ, δ- or δ, ε-unsaturated carboxylic acid with halogen afford halolactone in high yield. This halolactonization reaction generally proceeds in a high stereo- and regiospecific manner. This makes the reaction one of the most important procedures for the functionalization of the carbon-carbon double bond.
This review provides illustrative examples of the synthesis of natural products where halolactonization reaction plays an important role.
Some related reactions are also described.
