Total Syntheses of Some Natural Products from Carbohydrates

Abstract

The utility of carbohydrates for stereospecific total syntheses of natural products is illustrated : (1) total syntheses of 16-membered-ring macrolide antibiotics (A 26771 B, carbomycin B, josamycin and tylosin) from D-glucose ; (2) total syntheses of pyrrolizidine alkaloid necine bases (rosmarinecine, 7-deoxyrosmarinecine and isoretronecanol) from D-glucosamine.