Syntheses of Constituent Mono-and Oligo-saccharides in Asparagine-linked Glycan of Glycoprotein

Abstract

This article describes synthetic methods for constituent mono-and oligo-saccharides existing in asparagine-linked glycan of glycoprotein. The target compounds are L-fucose, N-acetyllactosamine, di-N-acetylchitobiose, core pentasaccharide, and, di-and tri-mannopyranosyl-N-acetylglucosamines. Scope and limitation of chemical syntheses of oligosaccharides are generally discussed. Most of this article is based on the papers reported from this laboratory since 1979.