ファインケミカルズを指向する新しい高選択的合成プロセスの開発

カルボニル基への求核的反応におけるジアステレオ面の制御

抄録

The ever advancing development of chemical reactions has initiated enormous progress towards the stereoselective reactions. In almost cases, however, only one isomer of the possible two isomers can be obtained by these reactions and nowadays selective synthesis of both isomers is required. The present article reviews the current advancement for selective diastereoface differentiating reactions to give both isomers especially relating to nucleophilic addition reactions to carbonyl compounds with an asymmetric center. Fundamental significance is to utilize metal reagents possessing various coordinating abilities.