Recent Progress on the Synthesis of Leukotrienes.

Abstract

In the past several years, metabolites derived from arachidonic acid via the leukotriene (LT) cascade have attracted much interest in the scienticic community because of their biologically important nature. Since LTs are available in minute quantity from biological sources, much efforts have been paid for their chemical synthesis to evaluate their biological properties This review summarizes the recent progress on the chemical synthesis of LTs in their natural form, which includes epoxy LT (LTA₄), dihydroxy LT (LTB₄ and DiHETE), peptide LT (LTC₄-F₄), monohydro (pero) xy LT (H (P) ETE), lipoxins, hepoxilins, and trioxilins.