New Synthetic Methods of Cystine-containing Peptides.

Abstract

In terms of the efficient and/or unambiguous synthesis of complex peptides (proteins) containing several cystine residues, the existing methods are still less than satisfactory. Therefore one of our research interests has been focused on methodological improvements for the chemical synthesis of cystine peptides. We developed two new disulfide bond forming reactions; the one by thallium (III) oxidation and the other by acid catalyzed reaction involving S-protected cysteine sulfoxides, in addition developed a new S-deprotecting method by using AgOTf. We wish to describe three methods above mentioned and the applications for the syntheses of cystine-containing peptides.