Sialic Acid Derivatives for Novel Medicines

Abstract

Neu 5 Ac, the most important sialic acid was obtained from edible bird's nest, KDN was prepared from D-mannose and oxalacetic acid. KDN glycosides were synthesized by the Koenigs-Knorr reaction for cholesterol and Williamson method for phenols.
S, S′-Bis(1-phenyl-1H-tetrazol-5-yl) dithiocarbonate prepared from 5-mercapto-1-phenyl-1H-tetrazole and trichloromethyl chloroformate, was attempted to a novel glycosylation reagent. Sialosyllactose and sialosylcholesterol were synthesized by this method.
G_M3 cholesterol analog and mitomycin derivatives were synthesized.