パン酵母の特性を活かした不斉還元

高純度光学活性物質の調製

抄録

Preparations of optically pure short- to long-chain β-, γ-, and δ-hydroxy acids with R configuration, α-methyl-β-hydroxy acids with anti-2R, 3R configuration, 1, 2-alkanediols with R configuration, and 1-acetoxy-2-alkanols with S configuration are described, by use of asymmetric reduction of the corresponding keto compounds with bakers' yeast. The high optical purity of the products is attributable to the carboxy group in the keto acids and to the substrate specificity of the enzymes involved in the reductions, based on comparison of the keto acids and keto esters as substrates and isolation of the reducing enzymes from bakers' yeast.