1992 Volume 50 Issue 12 Pages 1140-1147
Concept of “Molecular Recognition” in the chemistry has originated from the biological functions such as specific catalytic behavior in enzymatic reaction, highly selective binding of a signal molecule to the receptor protein and transportation of substrate between different phases. From standpoint of the modern Host-Guest chemistry, organic reactions based on molecular recognition have received particular interest of organic chemists. Firstly molecular recognition in organic reactions involves complementary interaction between host and guest molecules through reversible non-covalent bonding at multi-binding sites. Secondly activation of substrate state requires cooperative interactions at the transition state. Some recent progress in organic reactions based on molecular recognition is briefly viewed for hydrolysis, oxidation, electron transfer and synthesis catalyzed by metal complexes.
