Optical Resolution by High-Performance Liquid Chromatography (HPLC) Using Polysaccharide Derivatives as Chiral Stationary Phases

Abstract

Polysaccharides such as cellulose and amylose are the most accessible optically active polymers. The polysaccharides themselves show rather low chiral recognition, but their derivatives show high chiral recognition and afford useful chiral stationary phases (CSPs) for HPLC. In this review, optical resolution by cellulose esters, especially benzoates, and by various phenylcarbamates of cellulose and amylose is discussed. Chiral recognition abilities of aralkylcarbamates of cellulose and amylose are also evaluated.