Total Syntheses of Highly Functionalized Natural Products

Abstract

This review mentions the total sytheses of the highly functionalized natural products, pederine, aplasmomycin, and virantmycin. The total synthesis of pederine was accomplished by employing the new method for stereocontrolled formation of N- (α-methoxyalkyl) amide. Based on the novel remote controlled asymmetric redutions of some chiral ketones, the formal total synthesis of aplasmomycin was achieved. The stereospecific total synthesis of virantmycin and its diastereomer were performed by using intramolecular addition reaction of nitrene to olefin, and relative stereochemistry of virantmycin was established unambiguouly.