Neocarzinostatin Complex : Chromophore Analogs, Binding Structure and Stabilization Mechanism

Abstract

Design, synthesis, and chemistry of neocarzinostatin chromophore analogs and their DNA cleaving abilities have been discussed. A Three dimensional solution structure of neocarzinostatin complex explicitly shows how the neocarzinostatin apoprotein binds and prevents the chromophore from decomposing. The suggested binding elements and stabilization mechanisms have been examined by the model studies.